6VTY
Crystal structure of Plasmodium falciparum dihydroorotate dehydrogenase bound with Inhibitor DSM483
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A, B, C, D | Dihydroorotate dehydrogenase (quinone), mitochondrial | polymer | 431 | 48946.8 | 4 | UniProt (Q08210) Pfam (PF01180) In PDB | Plasmodium falciparum (isolate 3D7) | DHOdehase,Dihydroorotate oxidase |
2 | A, B, C, D | ethyl 3,5-dimethyl-4-{[4-(trifluoromethyl)phenyl]methyl}-1H-pyrrole-2-carboxylate | non-polymer | 325.3 | 4 | Chemie (RLA) | |||
3 | A, B, C, D | FLAVIN MONONUCLEOTIDE | non-polymer | 456.3 | 4 | Chemie (FMN) | |||
4 | A, B, C, D | OROTIC ACID | non-polymer | 156.1 | 4 | Chemie (ORO) | |||
5 | water | water | 18.0 | 897 | Chemie (HOH) |
Sequence modifications
A, B, C, D: 158 - 569 (UniProt: Q08210)
PDB | External Database | Details |
---|---|---|
Met 139 | - | initiating methionine |
Gly 140 | - | expression tag |
His 141 | - | expression tag |
His 142 | - | expression tag |
His 143 | - | expression tag |
His 144 | - | expression tag |
His 145 | - | expression tag |
His 146 | - | expression tag |
Ala 147 | - | expression tag |
Glu 148 | - | expression tag |
Asn 149 | - | expression tag |
Leu 150 | - | expression tag |
Tyr 151 | - | expression tag |
Phe 152 | - | expression tag |
Gln 153 | - | expression tag |
Gly 154 | - | expression tag |
Ala 155 | - | expression tag |
Asp 156 | - | expression tag |
Pro 157 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 4 |
Total formula weight | 195787.2 | |
Non-Polymers* | Number of molecules | 12 |
Total formula weight | 3751.1 | |
All* | Total formula weight | 199538.3 |