6VTY

Crystal structure of Plasmodium falciparum dihydroorotate dehydrogenase bound with Inhibitor DSM483

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B, C, D (A, B, C, D)	Dihydroorotate dehydrogenase (quinone), mitochondrial	polymer	431	48946.8	4	UniProt (Q08210) Pfam (PF01180)	Plasmodium falciparum (isolate 3D7)	DHOdehase,Dihydroorotate oxidase
2	E, H, K, N (A, B, C, D)	ethyl 3,5-dimethyl-4-{[4-(trifluoromethyl)phenyl]methyl}-1H-pyrrole-2-carboxylate	non-polymer		325.3	4	Chemie (RLA)
3	F, I, L, O (A, B, C, D)	FLAVIN MONONUCLEOTIDE	non-polymer		456.3	4	Chemie (FMN)
4	G, J, M, P (A, B, C, D)	OROTIC ACID	non-polymer		156.1	4	Chemie (ORO)
5	Q, R, S, T (A, B, C, D)	water	water		18.0	897	Chemie (HOH)

Sequence modifications

A, B, C, D: 158 - 569 (UniProt: Q08210)

PDB	External Database	Details
Met 139	-	initiating methionine
Gly 140	-	expression tag
His 141	-	expression tag
His 142	-	expression tag
His 143	-	expression tag
His 144	-	expression tag
His 145	-	expression tag
His 146	-	expression tag
Ala 147	-	expression tag
Glu 148	-	expression tag
Asn 149	-	expression tag
Leu 150	-	expression tag
Tyr 151	-	expression tag
Phe 152	-	expression tag
Gln 153	-	expression tag
Gly 154	-	expression tag
Ala 155	-	expression tag
Asp 156	-	expression tag
Pro 157	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	4
	Total formula weight	195787.2
Non-Polymers*	Number of molecules	12
	Total formula weight	3751.1
All*	Total formula weight	199538.3

*Water molecules are not included.