6VS9
Mycobacterium tuberculosis dihydrofolate reductase in complex with 3-(piperidin-1-ylmethyl)benzoic acid(fragment 11)
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | Dihydrofolate reductase | polymer | 161 | 17893.3 | 2 | UniProt (A5U6B6) Pfam (PF00186) | Mycobacterium tuberculosis (strain ATCC 25177 / H37Ra) | |
| 2 | C, K (A, B) | 3-[(piperidin-1-yl)methyl]benzoic acid | non-polymer | 219.3 | 2 | Chemie (RK4) PubChem (409199) | |||
| 3 | D, L (A, B) | NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE | non-polymer | 743.4 | 2 | Chemie (NAP) PubChem (5885) PubChem (46936685) PubChem (4412) PubChem (90473931) PubChem (91972139) PubChem (145946263) PubChem (153311489) PubChem (174001641) PubChem (71717786) PubChem (165382010) | |||
| 4 | E, F (A) | COBALT (II) ION | non-polymer | 58.9 | 2 | Chemie (CO) PubChem (104729) | |||
| 5 | G, H, M (A, B) | PHOSPHATE ION | non-polymer | 95.0 | 3 | Chemie (PO4) PubChem (1061) | |||
| 6 | I (A) | GLYCEROL | non-polymer | 92.1 | 1 | Chemie (GOL) PubChem (753) | |||
| 7 | J (A) | SULFATE ION | non-polymer | 96.1 | 1 | Chemie (SO4) | |||
| 8 | N, O (A, B) | water | water | 18.0 | 246 | Chemie (HOH) |
Sequence modifications
A, B: 1 - 159 (UniProt: A5U6B6)
| PDB | External Database | Details |
|---|---|---|
| Met -1 | - | initiating methionine |
| Thr 0 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 35786.6 | |
| Non-Polymers* | Number of molecules | 11 |
| Total formula weight | 2516.3 | |
| All* | Total formula weight | 38302.9 |
