6VS3
JAK2 JH1 in complex with BL2-057
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A, B | Tyrosine-protein kinase JAK2 | polymer | 308 | 36455.4 | 2 | UniProt (O60674) Pfam (PF07714) In PDB | Homo sapiens (Human) | Janus kinase 2,JAK-2 |
2 | A, B | (3R)-3-cyclopentyl-3-[4-(2-{[4-(piperidin-4-yl)phenyl]amino}-7H-pyrrolo[2,3-d]pyrimidin-4-yl)-1H-pyrazol-1-yl]propanenitrile | non-polymer | 480.6 | 2 | Chemie (R6V) | |||
3 | water | water | 18.0 | 373 | Chemie (HOH) |
Sequence modifications
A, B: 840 - 1132 (UniProt: O60674)
PDB | External Database | Details |
---|---|---|
His 825 | - | expression tag |
His 826 | - | expression tag |
His 827 | - | expression tag |
His 828 | - | expression tag |
His 829 | - | expression tag |
His 830 | - | expression tag |
His 831 | - | expression tag |
His 832 | - | expression tag |
Glu 833 | - | expression tag |
Asn 834 | - | expression tag |
Leu 835 | - | expression tag |
Tyr 836 | - | expression tag |
Phe 837 | - | expression tag |
Gln 838 | - | expression tag |
Gly 839 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 2 |
Total formula weight | 72910.9 | |
Non-Polymers* | Number of molecules | 2 |
Total formula weight | 961.2 | |
All* | Total formula weight | 73872.1 |