6VRK

Cryo-EM structure of the wild-type human serotonin transporter complexed with Br-paroxetine and 8B6 Fab

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A	Sodium-dependent serotonin transporter	polymer	630	70371.3	1	UniProt (P31645) Pfam (PF03491) Pfam (PF00209) In PDB	Homo sapiens (Human)	SERT,5HT transporter,5HTT,Solute carrier family 6 member 4
2	C	8B6 antibody, light chain	polymer	214	23718.2	1	UniProt (A0A0U5BC76) Pfam (PF07686) Pfam (PF07654) In PDB	Mus musculus (Mouse)
3	B	8B6 antibody, heavy chain	polymer	221	23688.4	1		Mus musculus (Mouse)
4	A	2-acetamido-2-deoxy-beta-D-glucopyranose	non-polymer		221.2	2	Chemie (NAG)
5	A	DODECYL-BETA-D-MALTOSIDE	non-polymer		510.6	1	Chemie (LMT)
6	A	Br-paroxetine	non-polymer		390.3	1	Chemie (RFS)

Sequence modifications

C: 21 - 116 (PDB: 6VRK)
C: 117 - 234 (UniProt: A0A0U5BC76)

Contents of the asymmetric unit

Polymers	Number of chains	3
	Total formula weight	117777.9
Non-Polymers*	Number of molecules	4
	Total formula weight	1343.3
All*	Total formula weight	119121.2

*Water molecules are not included.