6VRE
Structure of ASK1 bound to BIO-1772961
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B | Mitogen-activated protein kinase kinase kinase 5 | polymer | 291 | 32763.4 | 2 | UniProt (Q99683) Pfam (PF00069) In PDB | Homo sapiens (Human) | Apoptosis signal-regulating kinase 1,ASK-1,MAPK/ERK kinase kinase 5,MEKK 5 |
| 2 | A | DIMETHYL SULFOXIDE | non-polymer | 78.1 | 1 | Chemie (DMS) | |||
| 3 | A, B | 3-methoxy-N-{6-[4-(propan-2-yl)-4H-1,2,4-triazol-3-yl]pyridin-2-yl}-1-(pyrazin-2-yl)-1H-pyrazole-4-carboxamide | non-polymer | 405.4 | 2 | Chemie (RFG) | |||
| 4 | water | water | 18.0 | 77 | Chemie (HOH) |
Sequence modifications
A, B: 661 - 951 (UniProt: Q99683)
| PDB | External Database | Details |
|---|---|---|
| Glu 838 | Thr 838 | conflict |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 65526.7 | |
| Non-Polymers* | Number of molecules | 3 |
| Total formula weight | 889.0 | |
| All* | Total formula weight | 66415.7 |
