6VPM

TPX2 residues 7-20 fused to Aurora A residues 116-389 with C290 disulfide bonded to compound 8-34, and in complex with AMP-PNP

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B	TPX2 fragment - Aurora A kinase domain fusion	polymer	292	33986.7	2	UniProt (Q9ULW0) UniProt (O14965) Pfam (PF00069) In PDB	Homo sapiens (Human)	Targeting protein for Xklp2,Aurora kinase A,Differentially expressed in cancerous and non-cancerous lung cells 2,DIL-2,Hepatocellular carcinoma-associated antigen 519,Hepatocellular carcinoma-associated antigen 90,Protein fls353,Restricted expression proliferation-associated protein 100,p100,Aurora 2,Aurora/IPL1-related kinase 1,hARK1,Breast tumor-amplified kinase,Serine/threonine-protein kinase 15,Serine/threonine-protein kinase 6,Serine/threonine-protein kinase aurora-A
2	A	MAGNESIUM ION	non-polymer		24.3	2	Chemie (MG)
3	A, B	ADENOSINE MONOPHOSPHATE	non-polymer		347.2	2	Chemie (AMP)
4	A, B	N~2~-[(2H-1,3-benzodioxol-5-yl)acetyl]-N-[(pyridin-4-yl)methyl]-L-cysteinamide	non-polymer		373.4	2	Chemie (R74)
5	A, B	MALONIC ACID	non-polymer		104.1	2	Chemie (MLA)
6		water	water		18.0	502	Chemie (HOH)

Sequence modifications

A, B: 7 - 20 (UniProt: Q9ULW0)

PDB	External Database	Details
Gly -4	-	expression tag
Ala -3	-	expression tag
His -2	-	expression tag
Met -1	-	expression tag

A, B: 116 - 389 (UniProt: O14965)

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	67973.5
Non-Polymers*	Number of molecules	8
	Total formula weight	1698.0
All*	Total formula weight	69671.5

*Water molecules are not included.