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6VPG

TPX2 residues 7-20 fused to Aurora A residues 116-389 in complex with AMP-PNP

Entity
Entity IDChain IDDescriptionTypeChain lengthFormula weightNumber of moleculesDB Name (Accession)Biological sourceDescriptive keywords
1A
(A)
TPX2 fragment - Aurora A kinase domain fusionpolymer29234066.71UniProt (Q9ULW0)
UniProt (O14965)
Pfam (PF00069)
Homo sapiens (Human)Targeting protein for Xklp2,Aurora kinase A,Differentially expressed in cancerous and non-cancerous lung cells 2,DIL-2,Hepatocellular carcinoma-associated antigen 519,Hepatocellular carcinoma-associated antigen 90,Protein fls353,Restricted expression proliferation-associated protein 100,p100,Aurora 2,Aurora/IPL1-related kinase 1,hARK1,Breast tumor-amplified kinase,Serine/threonine-protein kinase 15,Serine/threonine-protein kinase 6,Serine/threonine-protein kinase aurora-A
2B
(A)
PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTERnon-polymer506.21Chemie (ANP)
3C
(A)
GLYCEROLnon-polymer92.11Chemie (GOL)
4D, E
(A)
CHLORIDE IONnon-polymer35.52Chemie (CL)
5F
(A)
MAGNESIUM IONnon-polymer24.31Chemie (MG)
6G
(A)
waterwater18.063Chemie (HOH)
Sequence modifications
A: 7 - 20 (UniProt: Q9ULW0)
PDBExternal DatabaseDetails
Gly 3-expression tag
Ala 4-expression tag
His 5-expression tag
Met 6-expression tag
A: 116 - 389 (UniProt: O14965)
Sequence viewer
Contents of the asymmetric unit
PolymersNumber of chains1
Total formula weight34066.7
Non-Polymers*Number of molecules5
Total formula weight693.5
All*Total formula weight34760.2
*Water molecules are not included.

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PDB entries from 2024-11-13

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