6VPG

TPX2 residues 7-20 fused to Aurora A residues 116-389 in complex with AMP-PNP

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A	TPX2 fragment - Aurora A kinase domain fusion	polymer	292	34066.7	1	UniProt (Q9ULW0) UniProt (O14965) Pfam (PF00069) In PDB	Homo sapiens (Human)	Targeting protein for Xklp2,Aurora kinase A,Differentially expressed in cancerous and non-cancerous lung cells 2,DIL-2,Hepatocellular carcinoma-associated antigen 519,Hepatocellular carcinoma-associated antigen 90,Protein fls353,Restricted expression proliferation-associated protein 100,p100,Aurora 2,Aurora/IPL1-related kinase 1,hARK1,Breast tumor-amplified kinase,Serine/threonine-protein kinase 15,Serine/threonine-protein kinase 6,Serine/threonine-protein kinase aurora-A
2	A	PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER	non-polymer		506.2	1	Chemie (ANP)
3	A	GLYCEROL	non-polymer		92.1	1	Chemie (GOL)
4	A	CHLORIDE ION	non-polymer		35.5	2	Chemie (CL)
5	A	MAGNESIUM ION	non-polymer		24.3	1	Chemie (MG)
6		water	water		18.0	63	Chemie (HOH)

Sequence modifications

A: 7 - 20 (UniProt: Q9ULW0)

PDB	External Database	Details
Gly 3	-	expression tag
Ala 4	-	expression tag
His 5	-	expression tag
Met 6	-	expression tag

A: 116 - 389 (UniProt: O14965)

Contents of the asymmetric unit

Polymers	Number of chains	1
	Total formula weight	34066.7
Non-Polymers*	Number of molecules	5
	Total formula weight	693.5
All*	Total formula weight	34760.2

*Water molecules are not included.