6VNQ
Crystal Structure of Danio rerio Histone Deacetylase 10 in Complex with Bishydroxamic Acid Based Inhibitor
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A | Polyamine deacetylase HDAC10 | polymer | 676 | 75055.6 | 1 | UniProt (F1QCV2) Pfam (PF00850) In PDB | Danio rerio (Zebrafish) | Histone deacetylase 10 |
2 | A | N-hydroxy-1-{[4-(hydroxycarbamoyl)phenyl]methyl}-1H-indole-6-carboxamide | non-polymer | 325.3 | 1 | Chemie (R5G) | |||
3 | A | 1,2-ETHANEDIOL | non-polymer | 62.1 | 2 | Chemie (EDO) | |||
4 | A | ZINC ION | non-polymer | 65.4 | 1 | Chemie (ZN) | |||
5 | A | POTASSIUM ION | non-polymer | 39.1 | 2 | Chemie (K) | |||
6 | A | PHOSPHATE ION | non-polymer | 95.0 | 2 | Chemie (PO4) | |||
7 | water | water | 18.0 | 261 | Chemie (HOH) |
Sequence modifications
A: 2 - 675 (UniProt: F1QCV2)
PDB | External Database | Details |
---|---|---|
Ala 1 | - | expression tag |
Glu 24 | Ala 24 | engineered mutation |
Ala 94 | Asp 94 | engineered mutation |
Phe 154 | Ile 154 | conflict |
Thr 548 | Ser 548 | conflict |
Glu 586 | Gly 586 | conflict |
Arg 593 | Gly 593 | conflict |
Arg 596 | Thr 596 | conflict |
Met 613 | Thr 613 | conflict |
Pro 646 | Leu 646 | conflict |
Trp 676 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 1 |
Total formula weight | 75055.6 | |
Non-Polymers* | Number of molecules | 8 |
Total formula weight | 783.0 | |
All* | Total formula weight | 75838.6 |