6VNE

JAK2 JH1 in complex with Fedratinib

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	B, A	Tyrosine-protein kinase JAK2	polymer	308	36455.4	2	UniProt (O60674) Pfam (PF07714) In PDB	Homo sapiens (Human)	Janus kinase 2,JAK-2
2	B, A	N-tert-butyl-3-{[5-methyl-2-({4-[2-(pyrrolidin-1-yl)ethoxy]phenyl}amino)pyrimidin-4-yl]amino}benzenesulfonamide	non-polymer		524.7	2	Chemie (2TA)
3		water	water		18.0	34	Chemie (HOH)

Sequence modifications

B, A: 840 - 1132 (UniProt: O60674)

PDB	External Database	Details
His 825	-	expression tag
His 826	-	expression tag
His 827	-	expression tag
His 828	-	expression tag
His 829	-	expression tag
His 830	-	expression tag
His 831	-	expression tag
His 832	-	expression tag
Glu 833	-	expression tag
Asn 834	-	expression tag
Leu 835	-	expression tag
Tyr 836	-	expression tag
Phe 837	-	expression tag
Gln 838	-	expression tag
Gly 839	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	72910.9
Non-Polymers*	Number of molecules	2
	Total formula weight	1049.4
All*	Total formula weight	73960.2

*Water molecules are not included.