6VLV
Factor XIa in complex with compound 11
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Coagulation factor XIa light chain | polymer | 238 | 26856.5 | 1 | UniProt (P03951) Pfam (PF00089) | Homo sapiens (Human) | FXI,Plasma thromboplastin antecedent,PTA |
| 2 | B, C (A) | CITRATE ANION | non-polymer | 189.1 | 2 | Chemie (FLC) | |||
| 3 | D (A) | 1-carbamimidamido-4-chloro-N-[(2R)-3-methyl-1-(morpholin-4-yl)-1-oxobutan-2-yl]isoquinoline-7-sulfonamide | non-polymer | 469.0 | 1 | Chemie (R3A) | |||
| 4 | E (A) | water | water | 18.0 | 217 | Chemie (HOH) |
Sequence modifications
A: 388 - 625 (UniProt: P03951)
| PDB | External Database | Details |
|---|---|---|
| Ser 500 | Cys 500 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 26856.5 | |
| Non-Polymers* | Number of molecules | 3 |
| Total formula weight | 847.2 | |
| All* | Total formula weight | 27703.7 |
