6VLL

The crystal structure of the 2009/H1N1/California PA endonuclease mutant I38T in complex with SJ000986213

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A (A)	Polymerase acidic protein	polymer	197	23136.3	1	UniProt (C6H0Y9) Pfam (PF00603)	Influenza A virus (A/Luxembourg/43/2009(H1N1))
2	B (A)	benzyl [2-(5-hydroxy-4-{[2-(2-methoxypyridin-4-yl)ethyl]carbamoyl}-6-oxo-1,6-dihydropyrimidin-2-yl)propan-2-yl]carbamate	non-polymer		481.5	1	Chemie (R3J)
3	C, D (A)	MANGANESE (II) ION	non-polymer		54.9	2	Chemie (MN)
4	E (A)	SULFATE ION	non-polymer		96.1	1	Chemie (SO4)
5	F (A)	water	water		18.0	23	Chemie (HOH)

Sequence modifications

A: 1 - 50 (UniProt: C6H0Y9)

PDB	External Database	Details
Met -19	-	expression tag
Gly -18	-	expression tag
Ser -17	-	expression tag
Ser -16	-	expression tag
His -15	-	expression tag
His -14	-	expression tag
His -13	-	expression tag
His -12	-	expression tag
His -11	-	expression tag
His -10	-	expression tag
Ser -9	-	expression tag
Ser -8	-	expression tag
Gly -7	-	expression tag
Leu -6	-	expression tag
Val -5	-	expression tag
Pro -4	-	expression tag
Arg -3	-	expression tag
Gly -2	-	expression tag
Ser -1	-	expression tag
His 0	-	expression tag
Thr 38	Ile 38	engineered mutation

A: 73 - 196 (UniProt: C6H0Y9)

PDB	External Database	Details
Gly 51	-	linker
Gly 52	-	linker
Ser 53	-	linker

Contents of the asymmetric unit

Polymers	Number of chains	1
	Total formula weight	23136.3
Non-Polymers*	Number of molecules	4
	Total formula weight	687.4
All*	Total formula weight	23823.7

*Water molecules are not included.