6VHG
Crystal structure of phosphorylated RET tyrosine kinase domain complexed with a pyrazolo[1,5-a]pyrimidine inhibitor
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A | Proto-oncogene tyrosine-protein kinase receptor Ret | polymer | 311 | 35528.8 | 1 | UniProt (P07949) Pfam (PF07714) In PDB | Homo sapiens (Human) | Cadherin family member 12,Proto-oncogene c-Ret |
| 2 | A | 3-(3,4-dimethoxyphenyl)-N~5~-(1-methylpiperidin-4-yl)-6-phenylpyrazolo[1,5-a]pyrimidine-5,7-diamine | non-polymer | 458.6 | 1 | Chemie (QX1) | |||
| 3 | A | SULFATE ION | non-polymer | 96.1 | 4 | Chemie (SO4) | |||
| 4 | A | CHLORIDE ION | non-polymer | 35.5 | 2 | Chemie (CL) | |||
| 5 | A | ACETATE ION | non-polymer | 59.0 | 1 | Chemie (ACT) | |||
| 6 | water | water | 18.0 | 133 | Chemie (HOH) |
Sequence modifications
A: 705 - 1013 (UniProt: P07949)
| PDB | External Database | Details |
|---|---|---|
| Gly 703 | - | expression tag |
| Ala 704 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 35528.8 | |
| Non-Polymers* | Number of molecules | 8 |
| Total formula weight | 972.8 | |
| All* | Total formula weight | 36501.5 |
