6VG0
CRYSTAL STRUCTURE OF HUMAN CYTOSOLIC ISOCITRATE DEHYDROGENASE (IDH1) R132H MUTANT IN COMPLEX WITH NADPH and AGI-15056
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B, C (A, B, C) | Isocitrate dehydrogenase [NADP] cytoplasmic | polymer | 425 | 48135.7 | 3 | UniProt (O75874) Pfam (PF00180) | Homo sapiens (Human) | IDH,Cytosolic NADP-isocitrate dehydrogenase,IDP,NADP(+)-specific ICDH,Oxalosuccinate decarboxylase |
| 2 | D, F, H (A, B, C) | NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE | non-polymer | 745.4 | 3 | Chemie (NDP) | |||
| 3 | E, G (B, C) | N~2~,N~4~-bis[(1R)-1-cyclopropylethyl]-6-[6-(trifluoromethyl)pyridin-2-yl]-1,3,5-triazine-2,4-diamine | non-polymer | 392.4 | 2 | Chemie (QWM) | |||
| 4 | I, J, K (A, B, C) | water | water | 18.0 | 98 | Chemie (HOH) |
Sequence modifications
A, B, C: 1 - 414 (UniProt: O75874)
| PDB | External Database | Details |
|---|---|---|
| His 132 | Arg 132 | engineered mutation |
| Ser 415 | - | expression tag |
| Leu 416 | - | expression tag |
| Glu 417 | - | expression tag |
| His 418 | - | expression tag |
| His 419 | - | expression tag |
| His 420 | - | expression tag |
| His 421 | - | expression tag |
| His 422 | - | expression tag |
| His 423 | - | expression tag |
| His 424 | - | expression tag |
| His 425 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 3 |
| Total formula weight | 144407.1 | |
| Non-Polymers* | Number of molecules | 5 |
| Total formula weight | 3021.1 | |
| All* | Total formula weight | 147428.2 |
