6VCV

Aspergillus fumigatus FKBP12 protein bound with APX879 in P1 space group

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B (A, B)	FK506-binding protein 1A	polymer	115	12426.0	2	UniProt (Q4WLV6) Pfam (PF00254)	Neosartorya fumigata (strain ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100)	FKBP,Peptidyl-prolyl cis-trans isomerase,PPIase,Rapamycin-binding protein
2	C, D (A, B)	N'-[(3S,4R,5S,8R,9E,12S,14S,15R,16S,18R,19R,26aS)-5,19-dihydroxy-3-{(1E)-1-[(1R,3R,4R)-4-hydroxy-3-methoxycyclohexyl]prop-1-en-2-yl}-14,16-dimethoxy-4,10,12,18-tetramethyl-1,20,21-trioxo-8-(prop-2-en-1-yl)-1,3,4,5,6,8,11,12,13,14,15,16,17,18,19,20,21,23,24,25,26,26a-docosahydro-7H-15,19-epoxypyrido[2,1-c][1,4]oxazacyclotricosin-7-ylidene]acetohydrazide	non-polymer		860.1	2	Chemie (R27)
3	E, F (A, B)	water	water		18.0	332	Chemie (HOH)

Sequence modifications

A, B: 1 - 112 (UniProt: Q4WLV6)

PDB	External Database	Details
Gly -2	-	expression tag
Ser -1	-	expression tag
His 0	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	24852.0
Non-Polymers*	Number of molecules	2
	Total formula weight	1720.2
All*	Total formula weight	26572.1

*Water molecules are not included.