6V8N
Crystal structure of the p300 acetyltransferase domain with AcCoA competitive inhibitor 17
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A | Histone acetyltransferase p300 | polymer | 349 | 40405.2 | 1 | UniProt (Q09472) Pfam (PF08214) In PDB | Homo sapiens (Human) | p300 HAT,E1A-associated protein p300,Histone butyryltransferase p300,Histone crotonyltransferase p300,Protein 2-hydroxyisobutyryltransferase p300,Protein propionyltransferase p300 |
| 2 | A | SULFATE ION | non-polymer | 96.1 | 2 | Chemie (SO4) | |||
| 3 | A | CHLORIDE ION | non-polymer | 35.5 | 1 | Chemie (CL) | |||
| 4 | A | (2R)-2-{[(2S)-2-(4-cyanophenyl)propyl]amino}-N-[5-(1-methyl-1H-pyrazol-4-yl)pyridin-2-yl]-2-phenylacetamide | non-polymer | 450.5 | 1 | Chemie (QS1) | |||
| 5 | water | water | 18.0 | 32 | Chemie (HOH) |
Sequence modifications
A: 1287 - 1666 (UniProt: Q09472)
| PDB | External Database | Details |
|---|---|---|
| Met 1286 | - | initiating methionine |
| - | Glu 1523 | deletion |
| - | Glu 1524 | deletion |
| - | Glu 1525 | deletion |
| - | Glu 1526 | deletion |
| - | Arg 1527 | deletion |
| - | Lys 1528 | deletion |
| - | Arg 1529 | deletion |
| - | Glu 1530 | deletion |
| - | Glu 1531 | deletion |
| - | Asn 1532 | deletion |
| - | Thr 1533 | deletion |
| - | Ser 1534 | deletion |
| - | Asn 1535 | deletion |
| - | Glu 1536 | deletion |
| - | Ser 1537 | deletion |
| - | Thr 1538 | deletion |
| - | Asp 1539 | deletion |
| - | Val 1540 | deletion |
| - | Thr 1541 | deletion |
| - | Lys 1542 | deletion |
| - | Gly 1543 | deletion |
| - | Asp 1544 | deletion |
| - | Ser 1545 | deletion |
| - | Lys 1546 | deletion |
| - | Asn 1547 | deletion |
| - | Ala 1548 | deletion |
| - | Lys 1549 | deletion |
| - | Lys 1550 | deletion |
| - | Lys 1551 | deletion |
| - | Asn 1552 | deletion |
| - | Asn 1553 | deletion |
| - | Lys 1554 | deletion |
| Gly 1652 | Met 1652 | conflict |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 40405.2 | |
| Non-Polymers* | Number of molecules | 4 |
| Total formula weight | 678.1 | |
| All* | Total formula weight | 41083.3 |
