6V8B

Crystal structure of the p300 acetyltransferase domain with AcCoA competitive inhibitor 1

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A	Histone acetyltransferase p300	polymer	349	40364.2	1	UniProt (Q09472) Pfam (PF08214) In PDB	Homo sapiens (Human)	p300 HAT,E1A-associated protein p300,Histone butyryltransferase p300,Histone crotonyltransferase p300,Protein 2-hydroxyisobutyryltransferase p300,Protein propionyltransferase p300
2	A	4-(2-{[(1R)-2-(1H-indol-3-yl)-2-oxo-1-phenylethyl]amino}ethyl)benzene-1-sulfonamide	non-polymer		433.5	1	Chemie (QRY)
3	A	CHLORIDE ION	non-polymer		35.5	2	Chemie (CL)
4	A	SULFATE ION	non-polymer		96.1	1	Chemie (SO4)

Sequence modifications

A: 1287 - 1666 (UniProt: Q09472)

PDB	External Database	Details
Met 1286	-	initiating methionine
-	Glu 1523	deletion
-	Glu 1524	deletion
-	Glu 1525	deletion
-	Glu 1526	deletion
-	Arg 1527	deletion
-	Lys 1528	deletion
-	Arg 1529	deletion
-	Glu 1530	deletion
-	Glu 1531	deletion
-	Asn 1532	deletion
-	Thr 1533	deletion
-	Ser 1534	deletion
-	Asn 1535	deletion
-	Glu 1536	deletion
-	Ser 1537	deletion
-	Thr 1538	deletion
-	Asp 1539	deletion
-	Val 1540	deletion
-	Thr 1541	deletion
-	Lys 1542	deletion
-	Gly 1543	deletion
-	Asp 1544	deletion
-	Ser 1545	deletion
-	Lys 1546	deletion
-	Asn 1547	deletion
-	Ala 1548	deletion
-	Lys 1549	deletion
-	Lys 1550	deletion
-	Lys 1551	deletion
-	Asn 1552	deletion
-	Asn 1553	deletion
-	Lys 1554	deletion
Gly 1652	Met 1652	engineered mutation

Contents of the asymmetric unit

Polymers	Number of chains	1
	Total formula weight	40364.2
Non-Polymers*	Number of molecules	4
	Total formula weight	600.5
All*	Total formula weight	40964.7

*Water molecules are not included.