6V6X

The crystal structure of the 2009 H1N1 PA endonuclease mutant I38T in complex with SJ000988632

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A	Polymerase acidic protein	polymer	197	23136.3	1	UniProt (C6H0Y9) Pfam (PF00603) In PDB	Influenza A virus (A/Luxembourg/43/2009(H1N1))
2	A	MANGANESE (II) ION	non-polymer		54.9	2	Chemie (MN)
3	A	N-[2-(6-amino-9H-purin-9-yl)ethyl]-5-hydroxy-6-oxo-2-[2-(trifluoromethyl)phenyl]-1,6-dihydropyrimidine-4-carboxamide	non-polymer		460.4	1	Chemie (QQP)
4	A	Hexa Vinylpyrrolidone K15	non-polymer		668.9	1	Chemie (QQ4)
5	A	SULFATE ION	non-polymer		96.1	2	Chemie (SO4)
6		water	water		18.0	23	Chemie (HOH)

Sequence modifications

A: 1 - 50 (UniProt: C6H0Y9)

PDB	External Database	Details
Met -19	-	expression tag
Gly -18	-	expression tag
Ser -17	-	expression tag
Ser -16	-	expression tag
His -15	-	expression tag
His -14	-	expression tag
His -13	-	expression tag
His -12	-	expression tag
His -11	-	expression tag
His -10	-	expression tag
Ser -9	-	expression tag
Ser -8	-	expression tag
Gly -7	-	expression tag
Leu -6	-	expression tag
Val -5	-	expression tag
Pro -4	-	expression tag
Arg -3	-	expression tag
Gly -2	-	expression tag
Ser -1	-	expression tag
His 0	-	expression tag
Thr 38	Ile 38	engineered mutation

A: 73 - 196 (UniProt: C6H0Y9)

PDB	External Database	Details
Gly 51	-	linker
Gly 52	-	linker
Ser 53	-	linker

Contents of the asymmetric unit

Polymers	Number of chains	1
	Total formula weight	23136.3
Non-Polymers*	Number of molecules	6
	Total formula weight	1431.2
All*	Total formula weight	24567.5

*Water molecules are not included.