6V6O
EGFR(T790M/V948R) in complex with LN2380
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | D, A, B, C, E... | Epidermal growth factor receptor | polymer | 327 | 37392.3 | 8 | UniProt (P00533) Pfam (PF07714) In PDB | Homo sapiens (Human) | Proto-oncogene c-ErbB-1,Receptor tyrosine-protein kinase erbB-1 |
| 2 | D, A, B, C, E... | CHLORIDE ION | non-polymer | 35.5 | 8 | Chemie (CL) | |||
| 3 | D, A, B, C, E... | N-[3-({4-[4-(4-fluorophenyl)-2-(3-hydroxypropyl)-1H-imidazol-5-yl]pyridin-2-yl}amino)-4-methoxyphenyl]propanamide | non-polymer | 489.5 | 8 | Chemie (QQM) | |||
| 4 | water | water | 18.0 | 1618 | Chemie (HOH) |
Sequence modifications
D, A, B, C, E, F, G, H: 696 - 1022 (UniProt: P00533)
| PDB | External Database | Details |
|---|---|---|
| Met 790 | Thr 790 | engineered mutation |
| Arg 948 | Val 948 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 8 |
| Total formula weight | 299138.3 | |
| Non-Polymers* | Number of molecules | 16 |
| Total formula weight | 4200.0 | |
| All* | Total formula weight | 303338.2 |
