6V66
EGFR(T790M/V948R) in complex with LN2899
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B, C, D (D, A, B, C) | Epidermal growth factor receptor | polymer | 327 | 37392.3 | 4 | UniProt (P00533) Pfam (PF07714) | Homo sapiens (Human) | Proto-oncogene c-ErbB-1,Receptor tyrosine-protein kinase erbB-1 |
| 2 | E, H, L, N (D, A, B, C) | CHLORIDE ION | non-polymer | 35.5 | 4 | Chemie (CL) | |||
| 3 | F, J (D, B) | 1,2-ETHANEDIOL | non-polymer | 62.1 | 2 | Chemie (EDO) | |||
| 4 | G, I, K, M (D, A, B, C) | N-{3-[(4-{4-(4-fluorophenyl)-2-[(2-methoxyethyl)sulfanyl]-1H-imidazol-5-yl}pyridin-2-yl)amino]-4-methoxyphenyl}propanamide | non-polymer | 521.6 | 4 | Chemie (QP1) | |||
| 5 | O, P, Q, R (D, A, B, C) | water | water | 18.0 | 988 | Chemie (HOH) |
Sequence modifications
D, A, B, C: 696 - 1022 (UniProt: P00533)
| PDB | External Database | Details |
|---|---|---|
| Met 790 | Thr 790 | engineered mutation |
| Arg 948 | Val 948 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 149569.1 | |
| Non-Polymers* | Number of molecules | 10 |
| Total formula weight | 2352.4 | |
| All* | Total formula weight | 151921.5 |
