6V5N
EGFR(T790M/V948R) in complex with LN2084
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | D, A, B, C | Epidermal growth factor receptor | polymer | 328 | 37479.4 | 4 | UniProt (P00533) Pfam (PF07714) In PDB | Homo sapiens (Human) | Proto-oncogene c-ErbB-1,Receptor tyrosine-protein kinase erbB-1 |
| 2 | D, A, B, C | 3-[4-(4-fluorophenyl)-5-(2-phenyl-1H-pyrrolo[2,3-b]pyridin-4-yl)-1H-imidazol-2-yl]propan-1-ol | non-polymer | 412.5 | 4 | Chemie (QP7) | |||
| 3 | D, A, B, C | CHLORIDE ION | non-polymer | 35.5 | 4 | Chemie (CL) | |||
| 4 | water | water | 18.0 | 257 | Chemie (HOH) |
Sequence modifications
D, A, B, C: 695 - 1022 (UniProt: P00533)
| PDB | External Database | Details |
|---|---|---|
| Met 790 | Thr 790 | engineered mutation |
| Arg 948 | Val 948 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 149917.5 | |
| Non-Polymers* | Number of molecules | 8 |
| Total formula weight | 1791.6 | |
| All* | Total formula weight | 151709.1 |
