6V2U
Crystal structure of the insect cell-expressed WT-BRAF kinase in complex with Dabrafenib
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | Serine/threonine-protein kinase B-raf | polymer | 283 | 32098.1 | 2 | UniProt (P15056) Pfam (PF07714) | Homo sapiens (Human) | Proto-oncogene B-Raf,p94,v-Raf murine sarcoma viral oncogene homolog B1 |
| 2 | C, E (A, B) | Dabrafenib | non-polymer | 519.6 | 2 | Chemie (P06) | |||
| 3 | D (A) | CHLORIDE ION | non-polymer | 35.5 | 1 | Chemie (CL) |
Sequence modifications
A, B: 445 - 723 (UniProt: P15056)
| PDB | External Database | Details |
|---|---|---|
| Gly 441 | - | expression tag |
| Gly 442 | - | expression tag |
| Gly 443 | - | expression tag |
| Arg 444 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 64196.2 | |
| Non-Polymers* | Number of molecules | 3 |
| Total formula weight | 1074.6 | |
| All* | Total formula weight | 65270.8 |
