6UZ6
Crystal structure of GLUN1/GLUN2A-4M mutant ligand-binding domain in complex with glycine and glutamate
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Glutamate receptor ionotropic, NMDA 1 | polymer | 292 | 33340.0 | 1 | UniProt (P35439) Pfam (PF10613) Pfam (PF00060) | Rattus norvegicus (Rat) | GluN1,Glutamate [NMDA] receptor subunit zeta-1,N-methyl-D-aspartate receptor subunit NR1,NMD-R1 |
| 2 | B (B) | Glutamate receptor ionotropic, NMDA 2A | polymer | 280 | 31606.2 | 1 | UniProt (Q00959) Pfam (PF10613) Pfam (PF00060) | Rattus norvegicus (Rat) | GluN2A,Glutamate [NMDA] receptor subunit epsilon-1,N-methyl D-aspartate receptor subtype 2A,NR2A |
| 3 | C (A) | GLYCINE | non-polymer | 75.1 | 1 | Chemie (GLY) | |||
| 4 | D (B) | GLUTAMIC ACID | non-polymer | 147.1 | 1 | Chemie (GLU) | |||
| 5 | E, F (A, B) | water | water | 18.0 | 607 | Chemie (HOH) |
Sequence modifications
A: 2 - 152 (UniProt: P35439)
A: 155 - 292 (UniProt: P35439)
B: 5 - 142 (UniProt: Q00959)
B: 145 - 284 (UniProt: Q00959)
| PDB | External Database | Details |
|---|---|---|
| Gly 1 | - | expression tag |
| PDB | External Database | Details |
|---|---|---|
| Gly 153 | - | linker |
| Thr 154 | - | linker |
| PDB | External Database | Details |
|---|---|---|
| Arg 17 | Ala 414 | engineered mutation |
| PDB | External Database | Details |
|---|---|---|
| Gly 143 | - | linker |
| Thr 144 | - | linker |
| Met 222 | Lys 738 | engineered mutation |
| Arg 224 | Gly 740 | engineered mutation |
| Lys 225 | Arg 741 | engineered mutation |
| Thr 242 | Ser 758 | conflict |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 64946.3 | |
| Non-Polymers* | Number of molecules | 2 |
| Total formula weight | 222.2 | |
| All* | Total formula weight | 65168.5 |
