6UYA
Crystal structure of Compound 19 bound to IRAK4
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A, B, C, D | Interleukin-1 receptor-associated kinase 4 | polymer | 320 | 36170.5 | 4 | UniProt (Q9NWZ3) Pfam (PF07714) In PDB | Homo sapiens (Human) | IRAK-4,Renal carcinoma antigen NY-REN-64 |
2 | A, B, C, D | N-{2-[(2R)-2-fluoro-3-hydroxy-3-methylbutyl]-6-(morpholin-4-yl)-1-oxo-2,3-dihydro-1H-isoindol-5-yl}pyrazolo[1,5-a]pyrimidine-3-carboxamide | non-polymer | 482.5 | 4 | Chemie (QL7) | |||
3 | B | SULFATE ION | non-polymer | 96.1 | 1 | Chemie (SO4) | |||
4 | water | water | 18.0 | 887 | Chemie (HOH) |
Sequence modifications
A, B, C, D: 160 - 460 (UniProt: Q9NWZ3)
PDB | External Database | Details |
---|---|---|
Met 144 | - | initiating methionine |
His 145 | - | expression tag |
His 146 | - | expression tag |
His 147 | - | expression tag |
His 148 | - | expression tag |
His 149 | - | expression tag |
His 150 | - | expression tag |
Gly 151 | - | expression tag |
Glu 152 | - | expression tag |
Asn 153 | - | expression tag |
Leu 154 | - | expression tag |
Tyr 155 | - | expression tag |
Phe 156 | - | expression tag |
Gln 157 | - | expression tag |
Gly 158 | - | expression tag |
Ser 159 | - | expression tag |
Gly 461 | - | expression tag |
Asn 462 | - | expression tag |
Ser 463 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 4 |
Total formula weight | 144682.1 | |
Non-Polymers* | Number of molecules | 5 |
Total formula weight | 2026.1 | |
All* | Total formula weight | 146708.2 |