6UVF
Crystal structure of BCL-XL bound to compound 12: (R)-2-(3-([1,1'-Biphenyl]-4-carbonyl)-3-(4-methylbenzyl)ureido)-3-((cyclohexylmethyl)sulfonyl)propanoic acid
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A, B, C, D, E... | Bcl-2-like protein 1 | polymer | 158 | 17918.0 | 12 | UniProt (Q07817) Pfam (PF02180) Pfam (PF00452) In PDB | Homo sapiens (Human) | Bcl2-L-1,Apoptosis regulator Bcl-X |
2 | D, E, F, A, G... | SULFATE ION | non-polymer | 96.1 | 22 | Chemie (SO4) | |||
3 | D, A, H, B, J... | 1,2-ETHANEDIOL | non-polymer | 62.1 | 7 | Chemie (EDO) | |||
4 | L, D, E, F, G... | (R)-2-(3-([1,1'-Biphenyl]-4-carbonyl)-3-(4-methylbenzyl)ureido)-3-((cyclohexylmethyl)sulfonyl)propanoic acid | non-polymer | 576.7 | 12 | Chemie (QHS) | |||
5 | water | water | 18.0 | 185 | Chemie (HOH) |
Sequence modifications
A, B, C, D, E, F, G, H, I, J, K, L: 1 - 26 (UniProt: Q07817)
A, B, C, D, E, F, G, H, I, J, K, L: 83 - 209 (UniProt: Q07817)
PDB | External Database | Details |
---|---|---|
Gly -5 | - | expression tag |
Pro -4 | - | expression tag |
Leu -3 | - | expression tag |
Gly -2 | - | expression tag |
Ser -1 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 12 |
Total formula weight | 215015.5 | |
Non-Polymers* | Number of molecules | 41 |
Total formula weight | 9468.3 | |
All* | Total formula weight | 224483.8 |