6UUW
Structure of human ATP citrate lyase E599Q mutant in complex with Mg2+, citrate, ATP and CoA
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B, C, D (A, B, C, D) | ATP-citrate synthase | polymer | 1101 | 120983.1 | 4 | UniProt (P53396) Pfam (PF16114) Pfam (PF02629) Pfam (PF00549) Pfam (PF00285) | Homo sapiens (Human) | ATP-citrate (pro-S-)-lyase,ACL,Citrate cleavage enzyme |
| 2 | E, I, L, P (A, B, C, D) | ADENOSINE-5'-DIPHOSPHATE | non-polymer | 427.2 | 4 | Chemie (ADP) | |||
| 3 | F, J, M, Q (A, B, C, D) | COENZYME A | non-polymer | 767.5 | 4 | Chemie (COA) | |||
| 4 | G, K, N, R (A, B, C, D) | (2S)-2-hydroxy-2-[2-oxo-2-(phosphonooxy)ethyl]butanedioic acid | non-polymer | 272.1 | 4 | Chemie (Y2A) | |||
| 5 | H, O (A, C) | UNKNOWN LIGAND | non-polymer | 2 | Chemie (UNL) | ||||
| 6 | S, T, U, V (A, B, C, D) | water | water | 18.0 | 27 | Chemie (HOH) |
Sequence modifications
A, B, C, D: 1 - 1101 (UniProt: P53396)
| PDB | External Database | Details |
|---|---|---|
| Gln 599 | Glu 599 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 483932.6 | |
| Non-Polymers* | Number of molecules | 14 |
| Total formula weight | 5867.4 | |
| All* | Total formula weight | 489799.9 |
