6UTG

Allosteric coupling between alpha-rings of the 20S proteasome, 20S singly capped with a PA26/V230F

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	1, 2, H, I, J...	Proteasome subunit beta	polymer	203	22294.8	14	UniProt (P28061) Pfam (PF00227) In PDB	Thermoplasma acidophilum	20S proteasome subunit B, 20S proteasome beta subunit, Proteasome core protein PsmB
2	A, B, C, D, E...	Proteasome subunit alpha	polymer	227	25125.6	7	UniProt (P25156) Pfam (PF10584) Pfam (PF00227) In PDB	Thermoplasma acidophilum	20S proteasome alpha subunit,Proteasome core protein PsmA
3	O, P, Q, R, S...	Proteasome activator protein PA26	polymer	228	24995.4	7	UniProt (Q9U8G2) Pfam (PF02252) In PDB	Trypanosoma brucei
4	a, b, c, d, e...	Proteasome subunit alpha	polymer	224	24718.2	7	UniProt (P25156) Pfam (PF10584) Pfam (PF00227) In PDB	Thermoplasma acidophilum	20S proteasome alpha subunit,Proteasome core protein PsmA

Sequence modifications

O, P, Q, R, S, T, U: 4 - 231 (UniProt: Q9U8G2)

PDB	External Database	Details
Val 49	Thr 49	conflict
Thr 226	Ser 226	conflict
Phe 230	Val 230	engineered mutation

a, b, c, d, e, f, g: 10 - 233 (UniProt: P25156)

PDB	External Database	Details
Ala 66	Lys 66	engineered mutation

Contents of the asymmetric unit

Polymers	Number of chains	35
	Total formula weight	836002.3
All*	Total formula weight	836002.3

*Water molecules are not included.