6USU

Crystal structure of GluN1/GluN2A ligand-binding domain in complex with L689,560 and glutamate

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A (A)	Glutamate receptor ionotropic, NMDA 1	polymer	292	33340.0	1	UniProt (P35439) Pfam (PF10613) Pfam (PF00060)	Rattus norvegicus (Rat)	GluN1,Glutamate [NMDA] receptor subunit zeta-1,N-methyl-D-aspartate receptor subunit NR1,NMD-R1
2	B (B)	Glutamate receptor ionotropic, NMDA 2A	polymer	283	31785.3	1	UniProt (Q00959) Pfam (PF10613) Pfam (PF00060)	Rattus norvegicus (Rat)	GluN2A,Glutamate [NMDA] receptor subunit epsilon-1,N-methyl D-aspartate receptor subtype 2A,NR2A
3	C (A)	(2R,4S)-5,7-dichloro-4-[(phenylcarbamoyl)amino]-1,2,3,4-tetrahydroquinoline-2-carboxylic acid	non-polymer		380.2	1	Chemie (QGM)
4	D (B)	GLUTAMIC ACID	non-polymer		147.1	1	Chemie (GLU)
5	E, F (A, B)	water	water		18.0	249	Chemie (HOH)

Sequence modifications

A: 2 - 152 (UniProt: P35439)

PDB	External Database	Details
Gly 1	-	expression tag

A: 155 - 292 (UniProt: P35439)

PDB	External Database	Details
Gly 153	-	linker
Thr 154	-	linker

B: 5 - 142 (UniProt: Q00959)

PDB	External Database	Details
Ser 4	-	expression tag

B: 145 - 286 (UniProt: Q00959)

PDB	External Database	Details
Gly 143	-	linker
Thr 144	-	linker
Thr 242	Ser 758	conflict

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	65125.3
Non-Polymers*	Number of molecules	2
	Total formula weight	527.4
All*	Total formula weight	65652.7

*Water molecules are not included.