6USQ
Telomerase Reverse Transcriptase binary complex with Y256A mutation, TERT:DNA
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Telomerase reverse transcriptase | polymer | 597 | 70553.7 | 1 | UniProt (Q0QHL8) Pfam (PF12009) Pfam (PF00078) Pfam (PF17984) | Tribolium castaneum (Red flour beetle) | Telomerase catalytic subunit |
| 2 | B (E) | DNA (5'-D(*GP*GP*TP*CP*AP*GP*GP*TP*CP*AP*GP*GP*TP*CP*A)-3') | polymer | 15 | 4650.0 | 1 | synthetic construct | ||
| 3 | C (F) | DNA/RNA (5'-R(*CP*UP*GP*AP*CP*CP*UP*GP*AP*C)-D(P*CP*T)-R(P*GP*AP*C)-D(P*C)-3') | polymer | 16 | 4999.1 | 1 | synthetic construct | ||
| 4 | D, E (F) | MAGNESIUM ION | non-polymer | 24.3 | 2 | Chemie (MG) | |||
| 5 | F (A) | water | water | 18.0 | 1 | Chemie (HOH) |
Sequence modifications
A: 1 - 596 (UniProt: Q0QHL8)
| PDB | External Database | Details |
|---|---|---|
| Gly 0 | - | expression tag |
| Ala 256 | Tyr 256 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 3 |
| Total formula weight | 80202.8 | |
| Non-Polymers* | Number of molecules | 2 |
| Total formula weight | 48.6 | |
| All* | Total formula weight | 80251.4 |
