6UQS
Serendipitous Discovery of Aryl Boronic Acids as beta-Lactamase Inhibitors
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Beta-lactamase | polymer | 375 | 41024.3 | 1 | UniProt (Q541D8) Pfam (PF00144) UniProt (by SIFTS) (P24735) | Pseudomonas aeruginosa | |
| 2 | B (A) | 2-hydroxyethyl hydrogen phenylboronate | non-polymer | 166.0 | 1 | Chemie (QFP) | |||
| 3 | C (A) | CHLORIDE ION | non-polymer | 35.5 | 1 | Chemie (CL) | |||
| 4 | D (A) | water | water | 18.0 | 539 | Chemie (HOH) |
Sequence modifications
A: 27 - 397 (UniProt: Q541D8)
| PDB | External Database | Details |
|---|---|---|
| Gly 23 | - | expression tag |
| Ser 24 | - | expression tag |
| Lys 25 | - | expression tag |
| Leu 26 | - | expression tag |
| Ala 397 | Arg 397 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 41024.3 | |
| Non-Polymers* | Number of molecules | 2 |
| Total formula weight | 201.4 | |
| All* | Total formula weight | 41225.8 |
