6UQR

Complex of IgE and Ligelizumab

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, C (A, C)	Ligelizumab	polymer	268	28965.7	2		Homo sapiens (Human)
2	B, D (B, D)	IgE	polymer	247	27550.9	2	UniProt (P01854) Pfam (PF07654)	Homo sapiens (Human)	Immunoglobulin heavy constant epsilon, Ig epsilon chain C region,Ig epsilon chain C region ND
3	E (E)	alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose	branched		910.8	1	In PDB GlyTouCan (G22768VO)
4	F (F)	alpha-D-mannopyranose-(1-3)-beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose	branched		748.7	1	In PDB GlyTouCan (G81315DD)

Sequence modifications

B, D: 328 - 545 (UniProt: P01854)

PDB	External Database	Details
Ala 299	-	expression tag
Pro 300	-	expression tag
Met 301	-	expression tag
Ala 302	-	expression tag
Glu 303	-	expression tag
Gly 304	-	expression tag
Gly 305	-	expression tag
Gly 306	-	expression tag
Gln 307	-	expression tag
Asn 308	-	expression tag
His 309	-	expression tag
His 310	-	expression tag
His 311	-	expression tag
His 312	-	expression tag
His 313	-	expression tag
His 314	-	expression tag
His 315	-	expression tag
His 316	-	expression tag
Gly 317	-	expression tag
Gly 318	-	expression tag
Glu 319	-	expression tag
Asn 320	-	expression tag
Leu 321	-	expression tag
Tyr 322	-	expression tag
Phe 323	-	expression tag
Gln 324	-	expression tag
Gly 325	-	expression tag
Gly 326	-	expression tag
Ser 327	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	4
	Total formula weight	113033.0
Branched	Number of molecules	2
	Total formula weight	1659.5
All*	Total formula weight	114692.6

*Water molecules are not included.