6UOK
Y271G DNA polymerase beta substrate complex with templating cytosine and incoming r8-oxo-GTP
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, F (B, T) | DNA (5'-D(*CP*CP*GP*AP*CP*CP*GP*CP*GP*CP*AP*TP*CP*AP*GP*C)-3') | polymer | 16 | 4829.1 | 2 | synthetic construct | ||
| 2 | B, G (C, P) | DNA (5'-D(*GP*CP*TP*GP*AP*TP*GP*CP*GP*(DOC))-3') | polymer | 10 | 3045.0 | 2 | synthetic construct | ||
| 3 | C, H (E, D) | DNA (5'-D(P*GP*TP*CP*GP*G)-3') | polymer | 5 | 1536.0 | 2 | synthetic construct | ||
| 4 | D, E (F, A) | DNA polymerase beta | polymer | 335 | 38135.6 | 2 | UniProt (P06746) Pfam (PF14716) Pfam (PF10391) Pfam (PF14792) Pfam (PF14791) | Homo sapiens (Human) | |
| 5 | I (B) | CHLORIDE ION | non-polymer | 35.5 | 1 | Chemie (CL) | |||
| 6 | J, K, O, T, U... (E, F, A) | SODIUM ION | non-polymer | 23.0 | 6 | Chemie (NA) | |||
| 7 | L, M, N, Q, R... (F, A) | MANGANESE (II) ION | non-polymer | 54.9 | 6 | Chemie (MN) | |||
| 8 | P, W (F, A) | 8-OXO-GUANOSINE-5'-TRIPHOSPHATE | non-polymer | 539.2 | 2 | Chemie (8GT) | |||
| 9 | S (A) | 1,2-ETHANEDIOL | non-polymer | 62.1 | 1 | Chemie (EDO) | |||
| 10 | Y (D) | MAGNESIUM ION | non-polymer | 24.3 | 1 | Chemie (MG) | |||
| 11 | AA, BA, CA, DA, EA... (C, F, A, T, P...) | water | water | 18.0 | 47 | Chemie (HOH) |
Sequence modifications
F, A: 1 - 335 (UniProt: P06746)
| PDB | External Database | Details |
|---|---|---|
| Gly 271 | Tyr 271 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 8 |
| Total formula weight | 95091.4 | |
| Non-Polymers* | Number of molecules | 17 |
| Total formula weight | 1667.8 | |
| All* | Total formula weight | 96759.2 |
