6UMF
Crystal structure of human GAC in complex with inhibitor UPGL00012
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B, C, D | Glutaminase kidney isoform, mitochondrial | polymer | 527 | 58024.0 | 4 | UniProt (O94925) Pfam (PF17959) Pfam (PF04960) In PDB | Homo sapiens (Human) | GLS,K-glutaminase,L-glutamine amidohydrolase |
| 2 | B, C | N-(5-{[1-(5-amino-1,3,4-thiadiazol-2-yl)piperidin-4-yl]oxy}-1,3,4-thiadiazol-2-yl)-2-phenylacetamide | non-polymer | 417.5 | 2 | Chemie (QAM) | |||
| 3 | water | water | 18.0 | 125 | Chemie (HOH) |
Sequence modifications
A, B, C, D: 72 - 598 (UniProt: O94925)
| PDB | External Database | Details |
|---|---|---|
| Ala 268 | Val 268 | conflict |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 232096.0 | |
| Non-Polymers* | Number of molecules | 2 |
| Total formula weight | 835.0 | |
| All* | Total formula weight | 232931.0 |
