6UM3
Structure of Zika virus NS2b-NS3 protease mutant stabilizing the super-open conformation
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | NS2B-NS3 PROTEASE fusion | polymer | 241 | 25486.2 | 2 | UniProt (A0A1V0E2E5) UniProt (A0A219YLK5) Pfam (PF01002) Pfam (PF00949) UniProt (by SIFTS) (A0A024B7W1) | Zika virus (ZIKV) | |
| 2 | C (A) | 1,2-ETHANEDIOL | non-polymer | 62.1 | 1 | Chemie (EDO) | |||
| 3 | D, E (A, B) | water | water | 18.0 | 70 | Chemie (HOH) |
Sequence modifications
A, B: 48 - 990 (UniProt: A0A1V0E2E5)
A, B: 1001 - 1182 (UniProt: A0A219YLK5)
| PDB | External Database | Details |
|---|---|---|
| Gly 46 | - | expression tag |
| Ser 47 | - | expression tag |
| Ala 991 | - | linker |
| Gly 992 | - | linker |
| Gly 993 | - | linker |
| Gly 994 | - | linker |
| Gly 995 | - | linker |
| Ser 996 | - | linker |
| Gly 997 | - | linker |
| Gly 998 | - | linker |
| Gly 999 | - | linker |
| Gly 1000 | - | linker |
| PDB | External Database | Details |
|---|---|---|
| Ser 1080 | Cys 1578 | conflict |
| Cys 1088 | Ala 1586 | conflict |
| Ser 1143 | Cys 1641 | conflict |
| Cys 1157 | Lys 1655 | conflict |
| Ser 1178 | Cys 1676 | conflict |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 50972.5 | |
| Non-Polymers* | Number of molecules | 1 |
| Total formula weight | 62.1 | |
| All* | Total formula weight | 51034.6 |
