6ULR
Molecular basis for tumor infiltrating TCR recognition of hotspot KRAS-G12D mutation
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | HLA class I antigen | polymer | 274 | 31837.1 | 1 | UniProt (C1K0Y1) Pfam (PF00129) Pfam (PF07654) | Homo sapiens (Human) | MHC class I antigen,MHC class I histocompatibility antigen |
| 2 | B (B) | Beta-2-microglobulin | polymer | 99 | 11748.2 | 1 | UniProt (P61769) Pfam (PF07654) | Homo sapiens (Human) | |
| 3 | C (C) | GLY-ALA-ASP-GLY-VAL-GLY-LYS-SER-ALA | polymer | 9 | 761.8 | 1 | UniProt (P01111) | Homo sapiens | GTPase NRas |
| 4 | D (D) | TCR-V-alpha 4*01 | polymer | 206 | 22651.1 | 1 | Homo sapiens (Human) | ||
| 5 | E (E) | TCR-V-beta 5-6*01 | polymer | 244 | 27493.4 | 1 | Homo sapiens (Human) | ||
| 6 | F, G, H, I (A, B, D, E) | water | water | 18.0 | 25 | Chemie (HOH) |
Sequence modifications
C: 1 - 9 (UniProt: P01111)
| PDB | External Database | Details |
|---|---|---|
| Asp 3 | Gly 12 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 5 |
| Total formula weight | 94491.5 | |
| All* | Total formula weight | 94491.5 |
