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6ULK

Molecular basis for tumor infiltrating TCR recognition of hotspot KRAS-G12D mutation

Entity
Entity IDChain IDDescriptionTypeChain lengthFormula weightNumber of moleculesDB Name (Accession)Biological sourceDescriptive keywords
1A
(A)
HLA class I antigenpolymer27431837.11UniProt (C1K0Y1)
Pfam (PF00129)
Pfam (PF07654)
Homo sapiens (Human)MHC class I antigen,MHC class I histocompatibility antigen
2B
(B)
Beta-2-microglobulinpolymer10011879.41UniProt (P61769)
Pfam (PF07654)
Homo sapiens (Human)
3C
(C)
GLY-ALA-ASP-GLY-VAL-GLY-LYS-SER-ALA-LEUpolymer10875.01UniProt (P01111)Homo sapiens
4D, E, F
(A, B, C)
waterwater18.0148Chemie (HOH)
Sequence modifications
B: 1 - 99 (UniProt: P61769)
PDBExternal DatabaseDetails
Met 0-initiating methionine
C: 1 - 10 (UniProt: P01111)
PDBExternal DatabaseDetails
Asp 3Gly 12engineered mutation
Sequence viewer
Contents of the asymmetric unit
PolymersNumber of chains3
Total formula weight44591.4
All*Total formula weight44591.4
*Water molecules are not included.

238582

PDB entries from 2025-07-09

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