6UL8
RIP2 kinase catalytic domain complex with (5S,6S,8R)-2-(benzo[d]thiazol-5-yl)-6-hydroxy-4,5,6,7,8,9-hexahydro-5,8-methanopyrazolo[1,5-a][1,3]diazocine-3-carboxamide
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | Receptor-interacting serine/threonine-protein kinase 2 | polymer | 306 | 35194.5 | 2 | UniProt (O43353) Pfam (PF07714) | Homo sapiens (Human) | CARD-containing interleukin-1 beta-converting enzyme-associated kinase,CARD-containing IL-1 beta ICE-kinase,RIP-like-interacting CLARP kinase,Receptor-interacting protein 2,RIP-2,Tyrosine-protein kinase RIPK2 |
| 2 | C, E (A, B) | (5S,6S,8R)-2-(1,3-benzothiazol-5-yl)-6-hydroxy-4,5,6,7,8,9-hexahydro-5,8-methanopyrazolo[1,5-a][1,3]diazocine-3-carboxamide | non-polymer | 355.4 | 2 | Chemie (Q9J) | |||
| 3 | D (B) | CALCIUM ION | non-polymer | 40.1 | 1 | Chemie (CA) | |||
| 4 | F, G (A, B) | water | water | 18.0 | 121 | Chemie (HOH) |
Sequence modifications
A, B: 5 - 310 (UniProt: O43353)
| PDB | External Database | Details |
|---|---|---|
| Ser 7 | Cys 7 | engineered mutation |
| Cys 168 | Ser 168 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 70388.9 | |
| Non-Polymers* | Number of molecules | 3 |
| Total formula weight | 750.9 | |
| All* | Total formula weight | 71139.8 |
