6UJS

P-glycoprotein mutant-F728A and C952A-with BDE100

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A (A)	ATP-dependent translocase ABCB1	polymer	1282	141569.5	1	UniProt (P21447) Pfam (PF00664) Pfam (PF00005)	Mus musculus (Mouse)	ATP-binding cassette sub-family B member 1A,MDR1A,Multidrug resistance protein 1A,Multidrug resistance protein 3,P-glycoprotein 3,Phospholipid transporter ABCB1
2	B, C (A)	2,4-dibromophenyl 2,4,6-tribromophenyl ether	non-polymer		564.7	2	Chemie (4C8)

Sequence modifications

A: 1 - 1276 (UniProt: P21447)

PDB	External Database	Details
Gln 83	Asn 83	engineered mutation
Gln 87	Asn 87	engineered mutation
Gln 90	Asn 90	engineered mutation
Ala 728	Phe 728	engineered mutation
Ala 952	Cys 952	engineered mutation
His 1277	-	expression tag
His 1278	-	expression tag
His 1279	-	expression tag
His 1280	-	expression tag
His 1281	-	expression tag
His 1282	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	1
	Total formula weight	141569.5
Non-Polymers*	Number of molecules	2
	Total formula weight	1129.4
All*	Total formula weight	142698.9

*Water molecules are not included.