6UIB

Crystal structure of IL23 bound to peptide 23-652

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A (A)	Interleukin-23 subunit alpha	polymer	180	19997.5	1	UniProt (Q9NPF7) Pfam (PF16649)	Homo sapiens (Human)	IL-23-A,Interleukin-23 subunit p19,IL-23p19
2	B (B)	Interleukin-12 subunit beta	polymer	316	36041.3	1	UniProt (P29460) Pfam (PF10420)	Homo sapiens (Human)	IL-12B,Cytotoxic lymphocyte maturation factor 40 kDa subunit,CLMF p40,IL-12 subunit p40,NK cell stimulatory factor chain 2,NKSF2
3	C (C)	Peptide 23-652	polymer	20	2340.6	1		synthetic construct
4	D (D)	2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose	branched		424.4	1	In PDB GlyTouCan (G42666HT)
5	E, F, G (A, B, C)	water	water		18.0	26	Chemie (HOH)

Sequence modifications

A: 1 - 170 (UniProt: Q9NPF7)

PDB	External Database	Details
Asp -3	-	expression tag
Arg -2	-	expression tag
Ser -1	-	expression tag
Leu 0	-	expression tag
His 171	-	expression tag
His 172	-	expression tag
His 173	-	expression tag
His 174	-	expression tag
His 175	-	expression tag
His 176	-	expression tag

B: 1 - 306 (UniProt: P29460)

PDB	External Database	Details
Asp -3	-	expression tag
Arg -2	-	expression tag
Ser -1	-	expression tag
Leu 0	-	expression tag
His 307	-	expression tag
His 308	-	expression tag
His 309	-	expression tag
His 310	-	expression tag
His 311	-	expression tag
His 312	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	3
	Total formula weight	58379.5
Branched	Number of molecules	1
	Total formula weight	424.4
All*	Total formula weight	58803.9

*Water molecules are not included.