6UGZ
Human Carbonic Anhydrase IX-mimic complexed with SB4-208
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Carbonic anhydrase IX-mimic | polymer | 257 | 28844.5 | 1 | UniProt (P00918) Pfam (PF00194) | Homo sapiens | |
| 2 | B (A) | ZINC ION | non-polymer | 65.4 | 1 | Chemie (ZN) | |||
| 3 | C (A) | 7-fluoro-1lambda~6~,2,4-benzothiadiazine-1,1,3(2H,4H)-trione | non-polymer | 216.2 | 1 | Chemie (Q71) | |||
| 4 | D (A) | water | water | 18.0 | 187 | Chemie (HOH) |
Sequence modifications
A: 4 - 261 (UniProt: P00918)
| PDB | External Database | Details |
|---|---|---|
| Ser 65 | Ala 65 | engineered mutation |
| Gln 67 | Asn 67 | engineered mutation |
| Thr 69 | Glu 69 | engineered mutation |
| Leu 91 | Ile 91 | engineered mutation |
| Val 131 | Phe 130 | engineered mutation |
| Glu 170 | Lys 169 | engineered mutation |
| Ala 204 | Leu 203 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 28844.5 | |
| Non-Polymers* | Number of molecules | 2 |
| Total formula weight | 281.6 | |
| All* | Total formula weight | 29126.1 |
