6UGX

Crystal structure of the Fc fragment of PF06438179/GP1111 an infliximab biosimilar in a primative orthorhombic crystal form, Lot A

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B	PF-06438179/GP1111 Fc	polymer	255	28361.3	2	UniProt (P0DOX5) Pfam (PF07654) In PDB	Homo sapiens (Human)
2	C	2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-3)-[2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose	branched		1463.3	1	In PDB GlyTouCan (G80858MF)
3	D	2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-6)-[alpha-D-mannopyranose-(1-3)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose	branched		1260.2	1	In PDB GlyTouCan (G45889JQ)
4	B	POTASSIUM ION	non-polymer		39.1	1	Chemie (K)
5	B	CHLORIDE ION	non-polymer		35.5	1	Chemie (CL)
6		water	water		18.0	339	Chemie (HOH)

Sequence modifications

A, B: 196 - 220 (PDB: 6UGX)
A, B: 221 - 450 (UniProt: P0DOX5)

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	56722.5
Branched	Number of molecules	2
	Total formula weight	2723.5
Non-Polymers*	Number of molecules	2
	Total formula weight	74.6
All*	Total formula weight	59520.6

*Water molecules are not included.