6UGO
Human Carbonic Anhydrase IX-mimic complexed with SB4-205
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Carbonic anhydrase IX-mimic | polymer | 257 | 28844.5 | 1 | UniProt (P00918) Pfam (PF00194) | Homo sapiens (Human) | |
| 2 | B (A) | ZINC ION | non-polymer | 65.4 | 1 | Chemie (ZN) | |||
| 3 | C, D, E (A) | 5,7-dimethyl-1lambda~6~,2,4-benzothiadiazine-1,1,3(2H,4H)-trione | non-polymer | 226.3 | 3 | Chemie (Q77) | |||
| 4 | F (A) | CITRIC ACID | non-polymer | 192.1 | 1 | Chemie (CIT) | |||
| 5 | G (A) | water | water | 18.0 | 179 | Chemie (HOH) |
Sequence modifications
A: 4 - 261 (UniProt: P00918)
| PDB | External Database | Details |
|---|---|---|
| Ser 65 | Ala 65 | engineered mutation |
| Gln 67 | Asn 67 | engineered mutation |
| Thr 69 | Glu 69 | engineered mutation |
| Leu 91 | Ile 91 | engineered mutation |
| Val 131 | Phe 130 | engineered mutation |
| Glu 170 | Lys 169 | engineered mutation |
| Ala 204 | Leu 203 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 28844.5 | |
| Non-Polymers* | Number of molecules | 5 |
| Total formula weight | 936.3 | |
| All* | Total formula weight | 29780.8 |
