6UEA
Structure of pentameric sIgA complex
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B, F, G, K... | Immunoglobulin heavy constant alpha 2 | polymer | 245 | 26682.1 | 10 | UniProt (P01877) Pfam (PF00047) Pfam (PF07654) In PDB | Homo sapiens (Human) | Ig alpha-2 chain C region,Ig alpha-2 chain C region BUT,Ig alpha-2 chain C region LAN |
| 2 | C | Polymeric immunoglobulin receptor | polymer | 591 | 65154.1 | 1 | UniProt (P01833) Pfam (PF07686) In PDB | Homo sapiens (Human) | Poly-Ig receptor,Hepatocellular carcinoma-associated protein TB6 |
| 3 | D | Immunoglobulin J chain | polymer | 137 | 15611.5 | 1 | UniProt (P01591) Pfam (PF15097) In PDB | Homo sapiens (Human) | Joining chain of multimeric IgA and IgM |
| 4 | M, O, P, R | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 424.4 | 4 | In PDB GlyTouCan (G42666HT) | |||
| 5 | N, Q, S | beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 586.5 | 3 | In PDB GlyTouCan (G15407YE) | |||
| 6 | C | 2-acetamido-2-deoxy-beta-D-glucopyranose | non-polymer | 221.2 | 2 | Chemie (NAG) |
Sequence modifications
A, B, F, G, K, L, E, H, I, J: 242 - 472 (UniProt: P01877)
C: 1 - 585 (UniProt: P01833)
| PDB | External Database | Details |
|---|---|---|
| Asp 228 | - | expression tag |
| Tyr 229 | - | expression tag |
| Lys 230 | - | expression tag |
| Asp 231 | - | expression tag |
| Asp 232 | - | expression tag |
| Asp 233 | - | expression tag |
| Asp 234 | - | expression tag |
| Lys 235 | - | expression tag |
| Leu 236 | - | expression tag |
| Val 237 | - | expression tag |
| Pro 238 | - | expression tag |
| Arg 239 | - | expression tag |
| Gly 240 | - | expression tag |
| Ser 241 | - | expression tag |
| Leu 451 | Met 319 | conflict |
| PDB | External Database | Details |
|---|---|---|
| His 586 | - | expression tag |
| His 587 | - | expression tag |
| His 588 | - | expression tag |
| His 589 | - | expression tag |
| His 590 | - | expression tag |
| His 591 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 12 |
| Total formula weight | 347587.0 | |
| Branched | Number of molecules | 7 |
| Total formula weight | 3457.2 | |
| Non-Polymers* | Number of molecules | 2 |
| Total formula weight | 442.4 | |
| All* | Total formula weight | 351486.7 |
