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6UD8

GluA2 in complex with its auxiliary subunit CNIH3 - with antagonist ZK200775

Entity
Entity IDChain IDDescriptionTypeChain lengthFormula weightNumber of moleculesDB Name (Accession)Biological sourceDescriptive keywords
1A, B, C, DGlutamate receptor 2polymer88999530.44UniProt (P19491)
Pfam (PF01094)
Pfam (PF10613)
Pfam (PF00060)
In PDB
Rattus norvegicus (Rat)GluR-2,AMPA-selective glutamate receptor 2,GluR-B,GluR-K2,Glutamate receptor ionotropic,AMPA 2,GluA2
2E, F, G, HProtein cornichon homolog 3polymer17420262.84UniProt (Q6ZWS4)
Pfam (PF03311)
In PDB
Mus musculus (Mouse)CNIH-3,Cornichon family AMPA receptor auxiliary protein 3
3A, B, C, D(2R)-2,3-dihydroxypropyl (9Z)-octadec-9-enoatenon-polymer356.54Chemie (OLC)
4A, B, C, D{[7-morpholin-4-yl-2,3-dioxo-6-(trifluoromethyl)-3,4-dihydroquinoxalin-1(2H)-yl]methyl}phosphonic acidnon-polymer409.34Chemie (ZK1)
5E, F, G, HCHOLESTEROLnon-polymer386.74Chemie (CLR)
Sequence modifications
A, B, C, D: -20 - 847 (UniProt: P19491)
PDBExternal DatabaseDetails
Arg 586Gln 607conflict
Asp 848-expression tag
Tyr 849-expression tag
Lys 850-expression tag
Asp 851-expression tag
Asp 852-expression tag
Asp 853-expression tag
Asp 854-expression tag
Lys 855-expression tag
Glu 856-expression tag
Gly 857-expression tag
Tyr 858-expression tag
Asn 859-expression tag
Val 860-expression tag
Tyr 861-expression tag
Gly 862-expression tag
Ile 863-expression tag
Glu 864-expression tag
Ser 865-expression tag
Val 866-expression tag
Lys 867-expression tag
Ile 868-expression tag
E, F, G, H: 1 - 160 (UniProt: Q6ZWS4)
PDBExternal DatabaseDetails
Gly 161-linker
Gly 162-linker
Arg 163-linker
Gly 164-linker
Gly 165-linker
Thr 166-expression tag
Glu 167-expression tag
Thr 168-expression tag
Ser 169-expression tag
Gln 170-expression tag
Val 171-expression tag
Ala 172-expression tag
Pro 173-expression tag
Ala 174-expression tag
Sequence viewer
Contents of the asymmetric unit
PolymersNumber of chains8
Total formula weight479172.6
Non-Polymers*Number of molecules12
Total formula weight4609.8
All*Total formula weight483782.4
*Water molecules are not included.

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PDB entries from 2024-07-17

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