6UD5

Crystal structure of human tryptophan 2,3-dioxygenase in complex with carbon monoxide and tryptophan

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B, C, D	Tryptophan 2,3-dioxygenase	polymer	380	45182.5	4	UniProt (P48775) Pfam (PF03301) In PDB	Homo sapiens (Human)	TDO, Tryptamin 2,3-dioxygenase, Tryptophan oxygenase, TRPO, Tryptophan pyrrolase, Tryptophanase
2	A, B, C, D	PROTOPORPHYRIN IX CONTAINING FE	non-polymer		616.5	4	Chemie (HEM)
3	A, B, C, D	CARBON MONOXIDE	non-polymer		28.0	4	Chemie (CMO)
4	A, B, C, D	TRYPTOPHAN	non-polymer		204.2	8	Chemie (TRP)
5		water	water		18.0	773	Chemie (HOH)

Sequence modifications

A, B, C, D: 18 - 389 (UniProt: P48775)

PDB	External Database	Details
Met 17	-	initiating methionine
Glu 390	-	expression tag
His 391	-	expression tag
His 392	-	expression tag
His 393	-	expression tag
His 394	-	expression tag
His 395	-	expression tag
His 396	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	4
	Total formula weight	180730.1
Non-Polymers*	Number of molecules	16
	Total formula weight	4211.8
All*	Total formula weight	184941.9

*Water molecules are not included.