6U7G

HCoV-229E RBD Class V in complex with human APN

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B (A, B)	Aminopeptidase N	polymer	906	103522.0	2	UniProt (P15144) Pfam (PF17900) Pfam (PF01433) Pfam (PF11838)	Homo sapiens (Human)	hAPN, Alanyl aminopeptidase, Aminopeptidase M, AP-M, Microsomal aminopeptidase, Myeloid plasma membrane glycoprotein CD13, gp150
2	C, D (C, D)	Spike protein	polymer	145	15848.2	2	UniProt (H1AG31) Pfam (PF01600) UniProt (by SIFTS) (Q1HVK2)	Human coronavirus 229E (HCoV-229E)
3	E, F, G, H (E, F, G, H)	2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose	branched		424.4	4	In PDB GlyTouCan (G42666HT)
4	I, O (A, B)	ZINC ION	non-polymer		65.4	2	Chemie (ZN)
5	J, K, L, M, N... (A, B, C, D)	2-acetamido-2-deoxy-beta-D-glucopyranose	non-polymer		221.2	13	Chemie (NAG)
6	AA, X, Y, Z (D, A, B, C)	water	water		18.0	801	Chemie (HOH)

Sequence modifications

A, B: 66 - 967 (UniProt: P15144)

PDB	External Database	Details
Gly 62	-	cloning artifact
Gly 63	-	cloning artifact
Arg 64	-	cloning artifact
Pro 65	-	cloning artifact

C, D: 293 - 433 (UniProt: H1AG31)

PDB	External Database	Details
Gly 289	-	cloning artifact
Gly 290	-	cloning artifact
Arg 291	-	cloning artifact
Pro 292	-	cloning artifact
Met 300	Thr 299	conflict
Thr 412	Ser 411	conflict
Gly 422	Val 421	conflict
Gln 428	Lys 427	conflict

Contents of the asymmetric unit

Polymers	Number of chains	4
	Total formula weight	238740.4
Branched	Number of molecules	4
	Total formula weight	1697.6
Non-Polymers*	Number of molecules	15
	Total formula weight	3006.5
All*	Total formula weight	243444.5

*Water molecules are not included.