6U74

BRD4-BD1 in complex with the cyclic peptide 3.1_2

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B, C, D (A, B, C, D)	Bromodomain-containing protein 4	polymer	146	17200.6	4	UniProt (O60885) Pfam (PF00439)	Homo sapiens (Human)	Protein HUNK1
2	E, F (E, F)	cyclic peptide 3.1_2	polymer	16	1916.3	2		synthetic construct
3	G, H, I, J, K... (A, B, C, D, E...)	water	water		18.0	457	Chemie (HOH)

Sequence modifications

A, B, C, D: 42 - 168 (UniProt: O60885)

PDB	External Database	Details
Gln 36	-	expression tag
Gly 37	-	expression tag
Pro 38	-	expression tag
Leu 39	-	expression tag
Gly 40	-	expression tag
Ser 41	-	expression tag
Pro 169	-	expression tag
Glu 170	-	expression tag
Phe 171	-	expression tag
Pro 172	-	expression tag
Gly 173	-	expression tag
Arg 174	-	expression tag
Leu 175	-	expression tag
Glu 176	-	expression tag
Arg 177	-	expression tag
Pro 178	-	expression tag
His 179	-	expression tag
Arg 180	-	expression tag
Asp 181	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	6
	Total formula weight	72635.1
All*	Total formula weight	72635.1

*Water molecules are not included.