6U6Y

Human SAMHD1 bound to ribo(CGCCU)-oligonucleotide

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B, C, D	Deoxynucleoside triphosphate triphosphohydrolase SAMHD1	polymer	533	61740.5	4	UniProt (Q9Y3Z3) Pfam (PF01966) In PDB	Homo sapiens (Human)	dNTPase,Dendritic cell-derived IFNG-induced protein,DCIP,Monocyte protein 5,MOP-5,SAM domain and HD domain-containing protein 1,hSAMHD1
2	E, G, F, H	RNA CGCCU	polymer	5	1522.0	4		synthetic construct
3	A, B, C, D	ZINC ION	non-polymer		65.4	4	Chemie (ZN)
4	A, B, C, D	2'-DEOXYADENOSINE 5'-TRIPHOSPHATE	non-polymer		491.2	4	Chemie (DTP)
5		water	water		18.0	209	Chemie (HOH)

Sequence modifications

A, B, C, D: 114 - 626 (UniProt: Q9Y3Z3)

PDB	External Database	Details
Met 94	-	initiating methionine
Trp 95	-	expression tag
Ser 96	-	expression tag
His 97	-	expression tag
Pro 98	-	expression tag
Gln 99	-	expression tag
Phe 100	-	expression tag
Glu 101	-	expression tag
Lys 102	-	expression tag
Gly 103	-	expression tag
Ser 104	-	expression tag
Gly 105	-	expression tag
Ser 106	-	expression tag
Glu 107	-	expression tag
Asn 108	-	expression tag
Leu 109	-	expression tag
Tyr 110	-	expression tag
Phe 111	-	expression tag
Gln 112	-	expression tag
Gly 113	-	expression tag
Ala 311	Asp 311	engineered mutation

Contents of the asymmetric unit

Polymers	Number of chains	8
	Total formula weight	253049.9
Non-Polymers*	Number of molecules	8
	Total formula weight	2226.4
All*	Total formula weight	255276.3

*Water molecules are not included.