6U5M
Discovery and optimization of salicyclic acid-derived sulfonamide inhibitors of the WDR5:MYC protein-protein interaction
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | WD repeat-containing protein 5 | polymer | 304 | 33492.0 | 2 | UniProt (P61964) Pfam (PF00400) | Homo sapiens (Human) | BMP2-induced 3-kb gene protein |
| 2 | C, D (A, B) | 5-bromo-2-hydroxy-N-[3-(methylsulfonyl)-5-(pentafluoro-lambda~6~-sulfanyl)phenyl]benzene-1-sulfonamide | non-polymer | 532.3 | 2 | Chemie (Q0S) | |||
| 3 | E, F (A, B) | water | water | 18.0 | 725 | Chemie (HOH) |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 66984.0 | |
| Non-Polymers* | Number of molecules | 2 |
| Total formula weight | 1064.6 | |
| All* | Total formula weight | 68048.7 |
