6U3B

1.7 Angstrom crystal structure of the Q135P Ca-CaM:CaV1.2 IQ domain complex

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A	Calmodulin-1	polymer	148	16690.3	1	UniProt (P0DP23) Pfam (PF13499) In PDB	Homo sapiens (Human)
2	B	Voltage-dependent L-type calcium channel subunit alpha-1C	polymer	37	4319.0	1	UniProt (Q13936) In PDB	Homo sapiens (Human)	Calcium channel, L type, alpha-1 polypeptide, isoform 1, cardiac muscle, Voltage-gated calcium channel subunit alpha Cav1.2
3	A, B	CALCIUM ION	non-polymer		40.1	5	Chemie (CA)
4		water	water		18.0	159	Chemie (HOH)

Sequence modifications

A: 1 - 148 (UniProt: P0DP23)

PDB	External Database	Details
Pro 135	Gln 136	engineered mutation

B: 1611 - 1644 (UniProt: Q13936)

PDB	External Database	Details
Ser 1608	-	expression tag
Asn 1609	-	expression tag
Ala 1610	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	21009.3
Non-Polymers*	Number of molecules	5
	Total formula weight	200.4
All*	Total formula weight	21209.7

*Water molecules are not included.