6U2N
PCSK9 in complex with compound 4
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | Proprotein convertase subtilisin/kexin type 9 | polymer | 707 | 76081.7 | 2 | UniProt (Q8NBP7) Pfam (PF05922) Pfam (PF00082) Pfam (PF18459) Pfam (PF18464) Pfam (PF18463) | Homo sapiens (Human) | Neural apoptosis-regulated convertase 1,NARC-1,Proprotein convertase 9,PC9,Subtilisin/kexin-like protease PC9 |
| 2 | C (B) | 4-{[(1R)-6-methoxy-1-methyl-1-{2-oxo-2-[(1,3-thiazol-2-yl)amino]ethyl}-1,2,3,4-tetrahydroisoquinolin-7-yl]oxy}benzoic acid | non-polymer | 453.5 | 1 | Chemie (PV7) | |||
| 3 | D, E (A, B) | water | water | 18.0 | 125 | Chemie (HOH) |
Sequence modifications
A, B: 31 - 692 (UniProt: Q8NBP7)
| PDB | External Database | Details |
|---|---|---|
| Ile 474 | Val 474 | engineered mutation |
| Glu 670 | Gly 670 | engineered mutation |
| Lys 693 | - | expression tag |
| Gly 694 | - | expression tag |
| Asn 695 | - | expression tag |
| Ser 696 | - | expression tag |
| Ala 697 | - | expression tag |
| Asp 698 | - | expression tag |
| Ile 699 | - | expression tag |
| Gln 700 | - | expression tag |
| His 701 | - | expression tag |
| Ser 702 | - | expression tag |
| Gly 703 | - | expression tag |
| Gly 704 | - | expression tag |
| Arg 705 | - | expression tag |
| Ser 706 | - | expression tag |
| Ser 707 | - | expression tag |
| Leu 708 | - | expression tag |
| Glu 709 | - | expression tag |
| Gly 710 | - | expression tag |
| Pro 711 | - | expression tag |
| Arg 712 | - | expression tag |
| Phe 713 | - | expression tag |
| Glu 714 | - | expression tag |
| Gly 715 | - | expression tag |
| Lys 716 | - | expression tag |
| Pro 717 | - | expression tag |
| Ile 718 | - | expression tag |
| Pro 719 | - | expression tag |
| Asn 720 | - | expression tag |
| Pro 721 | - | expression tag |
| Leu 722 | - | expression tag |
| Leu 723 | - | expression tag |
| Gly 724 | - | expression tag |
| Leu 725 | - | expression tag |
| Asp 726 | - | expression tag |
| Ser 727 | - | expression tag |
| Thr 728 | - | expression tag |
| Arg 729 | - | expression tag |
| Thr 730 | - | expression tag |
| Gly 731 | - | expression tag |
| His 732 | - | expression tag |
| His 733 | - | expression tag |
| His 734 | - | expression tag |
| His 735 | - | expression tag |
| His 736 | - | expression tag |
| His 737 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 152163.3 | |
| Non-Polymers* | Number of molecules | 1 |
| Total formula weight | 453.5 | |
| All* | Total formula weight | 152616.8 |
